Most NUC-sized systems rely on the on-board GPU found on many Intel and some Ryzen CPUs. They're going to have neither the onboard memory nor the horsepower to host an R1 model,
the requirements page I use says that an RTX3060 with 12GB of GPU RAM is the minimum for even the smallest R1 model.
Having said that, there are NUCs and there are
NUCs. Asus has been able to do some interesting things with the form factor ever since taking over Intel's NUC business, especially on its ROG gamer's side. Consider the
2025 ROG NUC which can sport an RTX5080.
Obviously there are tradeoffs, in both cost -- maybe 5x the price of your SER6 -- and how many watts can be pumped out of a NUC-factor power supply. A small desktop-sized PC might better cool and power such a rig and may even be cheaper, though y
ou might want to hold off on the current rev of the 5080/5090.