In my experience, Borg Backup is by far the most efficient and advanced backup solution. Although I prefer using Borg directly, many people choose Borgmatic [2], a Python wrapper for Borg that provides some additional niceties like pre-backup and post-backup hooks, backup of databases like PostgreSQL and MySQL/MariaDB and more. Very importantly, Borg enables backups to untrusted servers and from untrusted clients using the restricted ssh mechanism [3].

Borgmatic supports at least two hosting providers as of now [2]. Personally, I rclone my Borg backups to Amason S3.

[1] https://borgbackup.readthedocs.io/en/stable/

[2] https://torsion.org/borgmatic/

[3] https://borgbackup.readthedocs.io/en/stable/usage/serve.html