I never played Railroad Tycoon, but there's an open source version called OpenTTD and seems to be in active development.

On 29 November 2015 at 12:28, James Knott <james.knott@rogers.com> wrote:
On 11/29/2015 12:11 PM, Daniel Villarreal wrote:
> I found a neat use for the latest
> Knoppix, i.e. running old DOS games...
>
> https://ideas2learn.wordpress.com/notes_gaming/
>
It's long been possible to run DOS apps on Linux.  I have a game called
"Railroad Tychoon", from back in the '80s.  While it runs fine, because
it was intended for old DOS boxes, where VGA was the latest & greatest,
it only uses a small portion of my display.  I guess, for some reason,
the developers didn't foresee 1080p resolution on computer monitors.  ;-)